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p53 dynamics in single cells are temperature-sensitive

Cells need to preserve genome integrity despite varying cellular and physical states. p53, the guardian of the genome, plays a crucial role in the cellular response to DNA damage by triggering cell cycle arrest, apoptosis or senescence. Mutations in p53 or alterations in its regulatory network are m...

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Detalles Bibliográficos
Autores principales: Jentsch, Marcel, Snyder, Petra, Sheng, Caibin, Cristiano, Elena, Loewer, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992775/
https://www.ncbi.nlm.nih.gov/pubmed/32001771
http://dx.doi.org/10.1038/s41598-020-58267-1