AGO2 phosphorylation by c-Src kinase promotes tumorigenesis

Numerous studies have reported that c-Src is highly expressed with high tyrosine kinase activity in a variety of tumors. However, it remains unclear whether c-Src contributes to the miRNA pathway. Here, we report that c-Src can interact with and phosphorylate AGO2, a core component of RISC complex,...

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Detalles Bibliográficos
Autores principales: Liu, Tianqi, Zhang, Hailong, Fang, Jiayu, Yang, Zhi, Chen, Ran, Wang, Yanli, Zhao, Xian, Ge, Shengfang, Yu, Jianxiu, Huang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2020
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992904/
https://www.ncbi.nlm.nih.gov/pubmed/31981897
http://dx.doi.org/10.1016/j.neo.2019.12.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992904/
https://www.ncbi.nlm.nih.gov/pubmed/31981897
http://dx.doi.org/10.1016/j.neo.2019.12.004

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