R-Roscovitine Improves Motoneuron Function in Mouse Models for Spinal Muscular Atrophy

Neurotransmission defects and motoneuron degeneration are hallmarks of spinal muscular atrophy, a monogenetic disease caused by the deficiency of the SMN protein. In the present study, we show that systemic application of R-Roscovitine, a Ca(v)2.1/Ca(v)2.2 channel modifier and a cyclin-dependent kin...

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Detalles Bibliográficos
Autores principales: Tejero, Rocio, Balk, Stefanie, Franco-Espin, Julio, Ojeda, Jorge, Hennlein, Luisa, Drexl, Hans, Dombert, Benjamin, Clausen, Jan-Dierk, Torres-Benito, Laura, Saal-Bauernschubert, Lena, Blum, Robert, Briese, Michael, Appenzeller, Silke, Tabares, Lucia, Jablonka, Sibylle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992996/
https://www.ncbi.nlm.nih.gov/pubmed/31981925
http://dx.doi.org/10.1016/j.isci.2020.100826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992996/
https://www.ncbi.nlm.nih.gov/pubmed/31981925
http://dx.doi.org/10.1016/j.isci.2020.100826

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