CpG-Recoding in Zika Virus Genome Causes Host-Age-Dependent Attenuation of Infection With Protection Against Lethal Heterologous Challenge in Mice

Experimental increase of CpG dinucleotides in an RNA virus genome impairs infection providing a promising approach for vaccine development. While CpG recoding is an emerging and promising vaccine approach, little is known about infection phenotypes caused by recoded viruses in vivo. For example, inf...

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Detalles Bibliográficos
Autores principales: Trus, Ivan, Udenze, Daniel, Berube, Nathalie, Wheler, Colette, Martel, Marie-Jocelyne, Gerdts, Volker, Karniychuk, Uladzimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993062/
https://www.ncbi.nlm.nih.gov/pubmed/32038625
http://dx.doi.org/10.3389/fimmu.2019.03077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993062/
https://www.ncbi.nlm.nih.gov/pubmed/32038625
http://dx.doi.org/10.3389/fimmu.2019.03077

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