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D-4F, an ApoA-I mimetic peptide ameliorating TRPA1-mediated nocifensive behaviour in a model of neurogenic inflammation

BACKGROUND: High doses of capsaicin are recommended for the treatment of neuropathic pain. However, low doses evoke mechanical hypersensitivity. Activation of the capsaicin chemosensor transient receptor potential vanilloid 1 (TRPV1) induces neurogenic inflammation. In addition to the release of pro...

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Detalles Bibliográficos
Autores principales: Oehler, Beatrice, Kloka, Jan, Mohammadi, Milad, Ben-Kraiem, Adel, Rittner, Heike L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993174/
https://www.ncbi.nlm.nih.gov/pubmed/31996074
http://dx.doi.org/10.1177/1744806920903848