A review of thoracic aortic aneurysm disease

Aortic diseases may be diagnosed after a long period of subclinical development or they may have an acute presentation. Acute aortic syndrome is often the first sign of the disease, which needs rapid diagnosis and decision making to reduce the extremely poor prognosis. Aortic dilatation is a well-re...

Descripción completa

Detalles Bibliográficos
Autores principales: Clift, Paul F, Cervi, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993256/
https://www.ncbi.nlm.nih.gov/pubmed/32015897
http://dx.doi.org/10.1530/ERP-19-0049
_version_ 1783492992420544512
author Clift, Paul F
Cervi, Elena
author_facet Clift, Paul F
Cervi, Elena
author_sort Clift, Paul F
collection PubMed
description Aortic diseases may be diagnosed after a long period of subclinical development or they may have an acute presentation. Acute aortic syndrome is often the first sign of the disease, which needs rapid diagnosis and decision making to reduce the extremely poor prognosis. Aortic dilatation is a well-recognised risk factor for acute events and can occur as a result of trauma, infection, or, most commonly, from an intrinsic abnormality in the elastin and collagen components of the aortic wall. Over the years it has become clear that a few monogenic syndromes are strongly associated with aneurysms and often dictate a severe presentation in younger patients while the vast majority have a multifactorial pathogenesis. Conventional cardiovascular risk factors and ageing play an important role. Management strategy is based on prevention consisting of regular follow-up with cross-sectional imaging, chemoprophylaxis of further dilatation with drugs proved to slow down the disease progression and preventative surgery when dimension exceeds internationally recognised cut-off values for aortic diameters and the risk of rupture/dissection is therefore deemed very high.
format Online
Article
Text
id pubmed-6993256
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Bioscientifica Ltd
record_format MEDLINE/PubMed
spelling pubmed-69932562020-02-03 A review of thoracic aortic aneurysm disease Clift, Paul F Cervi, Elena Echo Res Pract Review Aortic diseases may be diagnosed after a long period of subclinical development or they may have an acute presentation. Acute aortic syndrome is often the first sign of the disease, which needs rapid diagnosis and decision making to reduce the extremely poor prognosis. Aortic dilatation is a well-recognised risk factor for acute events and can occur as a result of trauma, infection, or, most commonly, from an intrinsic abnormality in the elastin and collagen components of the aortic wall. Over the years it has become clear that a few monogenic syndromes are strongly associated with aneurysms and often dictate a severe presentation in younger patients while the vast majority have a multifactorial pathogenesis. Conventional cardiovascular risk factors and ageing play an important role. Management strategy is based on prevention consisting of regular follow-up with cross-sectional imaging, chemoprophylaxis of further dilatation with drugs proved to slow down the disease progression and preventative surgery when dimension exceeds internationally recognised cut-off values for aortic diameters and the risk of rupture/dissection is therefore deemed very high. Bioscientifica Ltd 2019-12-05 /pmc/articles/PMC6993256/ /pubmed/32015897 http://dx.doi.org/10.1530/ERP-19-0049 Text en © 2020 The authors http://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Review
Clift, Paul F
Cervi, Elena
A review of thoracic aortic aneurysm disease
title A review of thoracic aortic aneurysm disease
title_full A review of thoracic aortic aneurysm disease
title_fullStr A review of thoracic aortic aneurysm disease
title_full_unstemmed A review of thoracic aortic aneurysm disease
title_short A review of thoracic aortic aneurysm disease
title_sort review of thoracic aortic aneurysm disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993256/
https://www.ncbi.nlm.nih.gov/pubmed/32015897
http://dx.doi.org/10.1530/ERP-19-0049
work_keys_str_mv AT cliftpaulf areviewofthoracicaorticaneurysmdisease
AT cervielena areviewofthoracicaorticaneurysmdisease
AT cliftpaulf reviewofthoracicaorticaneurysmdisease
AT cervielena reviewofthoracicaorticaneurysmdisease