A review of thoracic aortic aneurysm disease
Aortic diseases may be diagnosed after a long period of subclinical development or they may have an acute presentation. Acute aortic syndrome is often the first sign of the disease, which needs rapid diagnosis and decision making to reduce the extremely poor prognosis. Aortic dilatation is a well-re...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Bioscientifica Ltd
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993256/ https://www.ncbi.nlm.nih.gov/pubmed/32015897 http://dx.doi.org/10.1530/ERP-19-0049 |
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author | Clift, Paul F Cervi, Elena |
author_facet | Clift, Paul F Cervi, Elena |
author_sort | Clift, Paul F |
collection | PubMed |
description | Aortic diseases may be diagnosed after a long period of subclinical development or they may have an acute presentation. Acute aortic syndrome is often the first sign of the disease, which needs rapid diagnosis and decision making to reduce the extremely poor prognosis. Aortic dilatation is a well-recognised risk factor for acute events and can occur as a result of trauma, infection, or, most commonly, from an intrinsic abnormality in the elastin and collagen components of the aortic wall. Over the years it has become clear that a few monogenic syndromes are strongly associated with aneurysms and often dictate a severe presentation in younger patients while the vast majority have a multifactorial pathogenesis. Conventional cardiovascular risk factors and ageing play an important role. Management strategy is based on prevention consisting of regular follow-up with cross-sectional imaging, chemoprophylaxis of further dilatation with drugs proved to slow down the disease progression and preventative surgery when dimension exceeds internationally recognised cut-off values for aortic diameters and the risk of rupture/dissection is therefore deemed very high. |
format | Online Article Text |
id | pubmed-6993256 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Bioscientifica Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-69932562020-02-03 A review of thoracic aortic aneurysm disease Clift, Paul F Cervi, Elena Echo Res Pract Review Aortic diseases may be diagnosed after a long period of subclinical development or they may have an acute presentation. Acute aortic syndrome is often the first sign of the disease, which needs rapid diagnosis and decision making to reduce the extremely poor prognosis. Aortic dilatation is a well-recognised risk factor for acute events and can occur as a result of trauma, infection, or, most commonly, from an intrinsic abnormality in the elastin and collagen components of the aortic wall. Over the years it has become clear that a few monogenic syndromes are strongly associated with aneurysms and often dictate a severe presentation in younger patients while the vast majority have a multifactorial pathogenesis. Conventional cardiovascular risk factors and ageing play an important role. Management strategy is based on prevention consisting of regular follow-up with cross-sectional imaging, chemoprophylaxis of further dilatation with drugs proved to slow down the disease progression and preventative surgery when dimension exceeds internationally recognised cut-off values for aortic diameters and the risk of rupture/dissection is therefore deemed very high. Bioscientifica Ltd 2019-12-05 /pmc/articles/PMC6993256/ /pubmed/32015897 http://dx.doi.org/10.1530/ERP-19-0049 Text en © 2020 The authors http://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Review Clift, Paul F Cervi, Elena A review of thoracic aortic aneurysm disease |
title | A review of thoracic aortic aneurysm disease |
title_full | A review of thoracic aortic aneurysm disease |
title_fullStr | A review of thoracic aortic aneurysm disease |
title_full_unstemmed | A review of thoracic aortic aneurysm disease |
title_short | A review of thoracic aortic aneurysm disease |
title_sort | review of thoracic aortic aneurysm disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993256/ https://www.ncbi.nlm.nih.gov/pubmed/32015897 http://dx.doi.org/10.1530/ERP-19-0049 |
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