Stimulated Biosynthesis of an C10-Deoxy Heptaene NPP B2 via Regulatory Genes Overexpression in Pseudonocardia autotrophica

Polyene macrolides, such as nystatin A1, amphotericin B, and NPP A1, belong to a large family of valuable antifungal polyketide compounds that are typically produced by soil actinomycetes. Previously, NPP B1, a novel NPP A1 derivative harboring a heptaene core structure, was generated by introducing...

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Detalles Bibliográficos
Autores principales: Park, Heung-Soon, Kim, Hye-Jin, Han, Chi-Young, Nah, Hee-Ju, Choi, Si-Sun, Kim, Eung-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993583/
https://www.ncbi.nlm.nih.gov/pubmed/32038598
http://dx.doi.org/10.3389/fmicb.2020.00019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993583/
https://www.ncbi.nlm.nih.gov/pubmed/32038598
http://dx.doi.org/10.3389/fmicb.2020.00019

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