Cargando…

The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6

Cholesterol synthesis is a tightly controlled pathway, with over 20 enzymes involved. Each of these enzymes can be distinctly regulated, helping to fine-tune the production of cholesterol and its functional intermediates. Several enzymes are degraded in response to increased sterol levels, whilst ot...

Descripción completa

Detalles Bibliográficos
Autores principales:	Scott, Nicola A., Sharpe, Laura J., Capell-Hattam, Isabelle M., Gullo, Samuel J., Luu, Winnie, Brown, Andrew J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2020
Materias:	Cell Homeostasis & Autophagy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993871/ https://www.ncbi.nlm.nih.gov/pubmed/31904814 http://dx.doi.org/10.1042/BCJ20190647

Ejemplares similares

METTL14 inhibits malignant progression of oral squamous cell carcinoma by targeting the autophagy-related gene RB1CC1 in an m6A-IGF2BP2-dependent manner
por: Liang, Jianfeng, et al.
Publicado: (2023)

Autophagy in asthma and chronic obstructive pulmonary disease
por: Barnes, Peter J., et al.
Publicado: (2022)

Autophagy attenuates high glucose-induced oxidative injury to lens epithelial cells
por: Liu, Xiaomin, et al.
Publicado: (2020)

Mechanism of sphingosine 1-phosphate clearance from blood
por: Kharel, Yugesh, et al.
Publicado: (2020)

The identification and characterisation of autophagy inhibitors from the published kinase inhibitor sets
por: Zachari, Maria, et al.
Publicado: (2020)

Chloroquine and bafilomycin A mimic lysosomal storage disorders and impair mTORC1 signalling
por: Fedele, Anthony O., et al.
Publicado: (2020)

Shensu IV prevents glomerular podocyte injury in nephrotic rats via promoting lncRNA H19/DIRAS3-mediated autophagy
por: Huang, Yong, et al.
Publicado: (2021)

Antimicrobial peptides with cell-penetrating activity as prophylactic and treatment drugs
por: del Rio, Gabriel, et al.
Publicado: (2022)

Peimine ameliorates pulmonary fibrosis via the inhibition of M2-type macrophage polarization through the suppression of P38/Akt/STAT6 signals
por: Cai, Ze-hui, et al.
Publicado: (2022)

Actin dynamics in protein homeostasis
por: Williams, Thomas D., et al.
Publicado: (2022)

The emerging role of LRRK2 in tauopathies
por: Herbst, Susanne, et al.
Publicado: (2022)

Autophagic degradation of membrane-bound organelles in plants
por: Wang, Jiaojiao, et al.
Publicado: (2023)

Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6
por: Qian, Lydia, et al.
Publicado: (2023)

Azole sensitivity in Leptosphaeria pathogens of oilseed rape: the role of lanosterol 14α-demethylase
por: Sewell, Thomas R., et al.
Publicado: (2017)

Structural and Functional Elucidation of Yeast Lanosterol 14α-Demethylase in Complex with Agrochemical Antifungals
por: Tyndall, Joel D. A., et al.
Publicado: (2016)

Increased intrinsic excitability of muscle vasoconstrictor preganglionic neurons may contribute to the elevated sympathetic activity in hypertensive rats
por: Briant, Linford J. B., et al.
Publicado: (2014)

An Erg11 lanosterol 14-α-demethylase-Arv1 complex is required for Candida albicans virulence
por: Villasmil, Michelle L., et al.
Publicado: (2020)

Absence of synergy for monosynaptic Group I inputs between abdominal and internal intercostal motoneurons
por: Ford, T. W., et al.
Publicado: (2014)

Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14α-demethylase
por: Sagatova, Alia A., et al.
Publicado: (2016)

Design, Synthesis and Antifungal Activity Evaluation of New Thiazolin-4-ones as Potential Lanosterol 14α-Demethylase Inhibitors
por: Stana, Anca, et al.
Publicado: (2017)

Intrinsic short-tailed azole resistance in mucormycetes is due to an evolutionary conserved aminoacid substitution of the lanosterol 14α-demethylase
por: Caramalho, Rita, et al.
Publicado: (2017)

Oxidation of Isodrimeninol with PCC Yields Drimane Derivatives with Activity against Candida Yeast by Inhibition of Lanosterol 14-Alpha Demethylase
por: Marin, Victor, et al.
Publicado: (2020)

Computational insights into fluconazole resistance by the suspected mutations in lanosterol 14α-demethylase (Erg11p) of Candida albicans
por: Prakash, Sagunthala Murugesan Udaya, et al.
Publicado: (2020)

Data on molecular docking of tautomers and enantiomers of ATTAF-1 and ATTAF-2 selectivty to the human/fungal lanosterol-14α-demethylase
por: Irannejad, Hamid, et al.
Publicado: (2020)

Ubiquitin Ligases in Cholesterol Metabolism
por: Jiang, Wei, et al.
Publicado: (2014)

Analysis of the ergosterol biosynthesis pathway cloning, molecular characterization and phylogeny of lanosterol 14 α-demethylase (ERG11) gene of Moniliophthora perniciosa
por: de Oliveira Ceita, Geruza, et al.
Publicado: (2014)

Structural Insights into the Azole Resistance of the Candida albicans Darlington Strain Using Saccharomyces cerevisiae Lanosterol 14α-Demethylase as a Surrogate
por: Graham, Danyon O., et al.
Publicado: (2021)

Phytochemical profiling of Piper crocatum and its antifungal mechanism action as Lanosterol 14 alpha demethylase CYP51 inhibitor: a review
por: Siswina, Tessa, et al.
Publicado: (2023)

Human Lanosterol 14-Alpha Demethylase (CYP51A1) Is a Putative Target for Natural Flavonoid Luteolin 7,3′-Disulfate
por: Kaluzhskiy, Leonid, et al.
Publicado: (2021)

Reduced Susceptibility to Azoles in Cryptococcus gattii Correlates with the Substitution R258L in a Substrate Recognition Site of the Lanosterol 14-α-Demethylase
por: Carvajal, Silvia Katherine, et al.
Publicado: (2023)

The Non Catalytic Protein ERG28 has a Functional Role in Cholesterol Synthesis and is Coregulated Transcriptionally
por: Capell-Hattam, Isabelle M., et al.
Publicado: (2022)

p62 at the crossroad of the ubiquitin-proteasome system and autophagy
por: Cohen-Kaplan, Victoria, et al.
Publicado: (2016)

Teorías y hechos sobre la vida : los sistemas vivos /
Publicado: (1988)

Toward improved phosphorus efficiency in monogastrics—interplay of serum, minerals, bone, and immune system after divergent dietary phosphorus supply in swine
por: Oster, Michael, et al.
Publicado: (2016)

Myo-inositol phosphate synthase expression in the European eel (Anguilla anguilla) and Nile tilapia (Oreochromis niloticus): effect of seawater acclimation
por: Kalujnaia, Svetlana, et al.
Publicado: (2016)

Functionalized Derivatives of Benzo-Crown Ethers. Part 4. Antifungal Macrocyclic Supramolecular Complexes of Transition Metal Ions Acting as Lanosterol-14-α-Demethylase Ihibitors
por: Barboiu, Mihai, et al.
Publicado: (1999)

Physiological substrates and ontogeny-specific expression of the ubiquitin ligases MARCH1 and MARCH8
por: Schriek, Patrick, et al.
Publicado: (2021)

Ubiquitination of HLA-DO by MARCH family E3 ligases
por: Jahnke, Martin, et al.
Publicado: (2013)

Ubiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy
por: Zheng, Jun, et al.
Publicado: (2021)

The mammalian cholesterol synthesis enzyme squalene monooxygenase is proteasomally truncated to a constitutively active form
por: Coates, Hudson W., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_01hisdkl9spah416bop21c696c