Improving the efficiency of gene insertion in a human artificial chromosome vector and its transfer in human-induced pluripotent stem cells

A human artificial chromosome (HAC) vector has potential to overcome the problems of stable gene expression associated with plasmid, transposon, and virus-based vectors, such as insertional mutagenesis, position effect, uncontrollable copy number, unstable gene expression, and DNA size limitation. T...

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Detalles Bibliográficos
Autores principales: Hasegawa, Yoshinori, Ikeno, Masashi, Suzuki, Nobutaka, Nakayama, Manabu, Ohara, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Methods Manuscript
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994043/
https://www.ncbi.nlm.nih.gov/pubmed/32161806
http://dx.doi.org/10.1093/biomethods/bpy013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994043/
https://www.ncbi.nlm.nih.gov/pubmed/32161806
http://dx.doi.org/10.1093/biomethods/bpy013

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