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Single-cell analysis reveals different age-related somatic mutation profiles between stem and differentiated cells in human liver
Accumulating somatic mutations have been implicated in age-related cellular degeneration and death. Because of their random nature and low abundance, somatic mutations are difficult to detect except in single cells or clonal cell lineages. Here, we show that in single hepatocytes from human liver, a...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994209/ https://www.ncbi.nlm.nih.gov/pubmed/32064334 http://dx.doi.org/10.1126/sciadv.aax2659 |