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Single-cell analysis reveals different age-related somatic mutation profiles between stem and differentiated cells in human liver

Accumulating somatic mutations have been implicated in age-related cellular degeneration and death. Because of their random nature and low abundance, somatic mutations are difficult to detect except in single cells or clonal cell lineages. Here, we show that in single hepatocytes from human liver, a...

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Detalles Bibliográficos
Autores principales: Brazhnik, K., Sun, S., Alani, O., Kinkhabwala, M., Wolkoff, A. W., Maslov, A. Y., Dong, X., Vijg, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994209/
https://www.ncbi.nlm.nih.gov/pubmed/32064334
http://dx.doi.org/10.1126/sciadv.aax2659

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