Molecular mechanism of SHP2 activation by PD-1 stimulation

In cancer, the programmed death-1 (PD-1) pathway suppresses T cell stimulation and mediates immune escape. Upon stimulation, PD-1 becomes phosphorylated at its immune receptor tyrosine–based inhibitory motif (ITIM) and immune receptor tyrosine–based switch motif (ITSM), which then bind the Src homol...

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Detalles Bibliográficos
Autores principales: Marasco, M., Berteotti, A., Weyershaeuser, J., Thorausch, N., Sikorska, J., Krausze, J., Brandt, H. J., Kirkpatrick, J., Rios, P., Schamel, W. W., Köhn, M., Carlomagno, T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994217/
https://www.ncbi.nlm.nih.gov/pubmed/32064351
http://dx.doi.org/10.1126/sciadv.aay4458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994217/
https://www.ncbi.nlm.nih.gov/pubmed/32064351
http://dx.doi.org/10.1126/sciadv.aay4458

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