Expression of Neprilysin in Skeletal Muscle by Ultrasound-Mediated Gene Transfer (Sonoporation) Reduces Amyloid Burden for AD

Amyloid β (Aβ) accumulation in the brain is considered to be one of the major pathological changes in the progression of Alzheimer’s disease (AD). Neprilysin (NEP) is a zinc metallopeptidase that efficiently degrades Aβ. However, conventional approaches for increasing NEP levels or inducing its acti...

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Detalles Bibliográficos
Autores principales: Li, Yuanli, Wang, Yadi, Wang, Jue, Chong, Ka Yee, Xu, Jingjing, Liu, Zhaohui, Shan, Chunlei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994414/
https://www.ncbi.nlm.nih.gov/pubmed/32021878
http://dx.doi.org/10.1016/j.omtm.2019.12.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994414/
https://www.ncbi.nlm.nih.gov/pubmed/32021878
http://dx.doi.org/10.1016/j.omtm.2019.12.012

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