Nuclear bodies formed by polyQ-ataxin-1 protein are liquid RNA/protein droplets with tunable dynamics

A mutant form of the ataxin-1 protein with an expanded polyglutamine (polyQ) tract is the underlying cause of the inherited neurodegenerative disease spinocerebellar ataxia 1 (SCA1). In probing the biophysical features of the nuclear bodies (NBs) formed by polyQ-ataxin-1, we defined ataxin-1 NBs as...

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Detalles Bibliográficos
Autores principales: Zhang, Sunyuan, Hinde, Elizabeth, Parkyn Schneider, Molly, Jans, David A., Bogoyevitch, Marie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994494/
https://www.ncbi.nlm.nih.gov/pubmed/32005838
http://dx.doi.org/10.1038/s41598-020-57994-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994494/
https://www.ncbi.nlm.nih.gov/pubmed/32005838
http://dx.doi.org/10.1038/s41598-020-57994-9

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