Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model

This study compared effects of five hypoxia-inducible factor (HIF) prolyl hydroxylases (PHD) inhibitors on PC12 cells and primary rat neurons following oxygen-glucose deprivation (OGD). At 100 µM, the PHD inhibitors did not cause cytotoxicity and apoptosis. MTT activity was only significantly reduce...

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Detalles Bibliográficos
Autores principales: Singh, Ayesha, Wilson, James W., Schofield, Christopher J., Chen, Ruoli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994562/
https://www.ncbi.nlm.nih.gov/pubmed/32005890
http://dx.doi.org/10.1038/s41598-020-58482-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994562/
https://www.ncbi.nlm.nih.gov/pubmed/32005890
http://dx.doi.org/10.1038/s41598-020-58482-w

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