The iron chelator Deferasirox causes severe mitochondrial swelling without depolarization due to a specific effect on inner membrane permeability

The iron chelator Deferasirox (DFX) causes severe toxicity in patients for reasons that were previously unexplained. Here, using the kidney as a clinically relevant in vivo model for toxicity together with a broad range of experimental techniques, including live cell imaging and in vitro biophysical...

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Detalles Bibliográficos
Autores principales: Gottwald, Esther M., Schuh, Claus D., Drücker, Patrick, Haenni, Dominik, Pearson, Adam, Ghazi, Susan, Bugarski, Milica, Polesel, Marcello, Duss, Michael, Landau, Ehud M., Kaech, Andres, Ziegler, Urs, Lundby, Anne K. M., Lundby, Carsten, Dittrich, Petra S., Hall, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994599/
https://www.ncbi.nlm.nih.gov/pubmed/32005861
http://dx.doi.org/10.1038/s41598-020-58386-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994599/
https://www.ncbi.nlm.nih.gov/pubmed/32005861
http://dx.doi.org/10.1038/s41598-020-58386-9

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