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Non-invasive Optical Biomarkers Distinguish and Track the Metabolic Status of Single Hematopoietic Stem Cells

Metabolism is a key regulator of hematopoietic stem cell (HSC) functions. There is a lack of real-time, non-invasive approaches to evaluate metabolism in single HSCs. Using fluorescence lifetime imaging microscopy, we developed a set of metabolic optical biomarkers (MOBs) from the auto-fluorescent p...

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Detalles Bibliográficos
Autores principales: Zhou, Hao, Nguyen, Lisa, Arnesano, Cosimo, Ando, Yuta, Raval, Manmeet, Rodgers, Joseph T., Fraser, Scott, Lu, Rong, Shen, Keyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994633/
https://www.ncbi.nlm.nih.gov/pubmed/31982780
http://dx.doi.org/10.1016/j.isci.2020.100831