Factors associated with false negative interferon-γ release assay results in patients with tuberculosis: A systematic review with meta-analysis
Which factors are related to false negative results of the interferon-γ release assay (IGRA) is unclear. This systematic review described the risk factors associated with false negative IGRA results. Two authors independently identified studies designed to evaluate risk factors for false negative IG...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994686/ https://www.ncbi.nlm.nih.gov/pubmed/32005930 http://dx.doi.org/10.1038/s41598-020-58459-9 |
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author | Yamasue, Mari Komiya, Kosaku Usagawa, Yuko Umeki, Kenji Nureki, Shin-ichi Ando, Masaru Hiramatsu, Kazufumi Nagai, Hideaki Kadota, Jun-ichi |
author_facet | Yamasue, Mari Komiya, Kosaku Usagawa, Yuko Umeki, Kenji Nureki, Shin-ichi Ando, Masaru Hiramatsu, Kazufumi Nagai, Hideaki Kadota, Jun-ichi |
author_sort | Yamasue, Mari |
collection | PubMed |
description | Which factors are related to false negative results of the interferon-γ release assay (IGRA) is unclear. This systematic review described the risk factors associated with false negative IGRA results. Two authors independently identified studies designed to evaluate risk factors for false negative IGRA results from PubMed, the Cochrane Register of Control Trial database, and EMBASE, accessed on October 22, 2018. Meta-analyses were conducted with random-effect models, and heterogeneity was calculated with the I(2) method. Of 1,377 titles and abstracts screened, 47 full texts were selected for review, and we finally included 17 studies in this systematic review. The most commonly studied risk factor (14 studies) was advanced age, followed by low peripheral lymphocyte counts (7 studies), and these factors were associated with false negative results even with different tuberculosis incidences (pooled odds ratio 2.06; 95% CI, 1.68–2.52 in advanced age and 2.68; 95% CI, 2.00–3.61 in low peripheral lymphocyte counts). Advanced age and low peripheral lymphocyte counts may be common risk factors for false negative IGRA results, suggesting that people with these factors need to be carefully followed, even if they have negative IGRA results. |
format | Online Article Text |
id | pubmed-6994686 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-69946862020-02-06 Factors associated with false negative interferon-γ release assay results in patients with tuberculosis: A systematic review with meta-analysis Yamasue, Mari Komiya, Kosaku Usagawa, Yuko Umeki, Kenji Nureki, Shin-ichi Ando, Masaru Hiramatsu, Kazufumi Nagai, Hideaki Kadota, Jun-ichi Sci Rep Article Which factors are related to false negative results of the interferon-γ release assay (IGRA) is unclear. This systematic review described the risk factors associated with false negative IGRA results. Two authors independently identified studies designed to evaluate risk factors for false negative IGRA results from PubMed, the Cochrane Register of Control Trial database, and EMBASE, accessed on October 22, 2018. Meta-analyses were conducted with random-effect models, and heterogeneity was calculated with the I(2) method. Of 1,377 titles and abstracts screened, 47 full texts were selected for review, and we finally included 17 studies in this systematic review. The most commonly studied risk factor (14 studies) was advanced age, followed by low peripheral lymphocyte counts (7 studies), and these factors were associated with false negative results even with different tuberculosis incidences (pooled odds ratio 2.06; 95% CI, 1.68–2.52 in advanced age and 2.68; 95% CI, 2.00–3.61 in low peripheral lymphocyte counts). Advanced age and low peripheral lymphocyte counts may be common risk factors for false negative IGRA results, suggesting that people with these factors need to be carefully followed, even if they have negative IGRA results. Nature Publishing Group UK 2020-01-31 /pmc/articles/PMC6994686/ /pubmed/32005930 http://dx.doi.org/10.1038/s41598-020-58459-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Yamasue, Mari Komiya, Kosaku Usagawa, Yuko Umeki, Kenji Nureki, Shin-ichi Ando, Masaru Hiramatsu, Kazufumi Nagai, Hideaki Kadota, Jun-ichi Factors associated with false negative interferon-γ release assay results in patients with tuberculosis: A systematic review with meta-analysis |
title | Factors associated with false negative interferon-γ release assay results in patients with tuberculosis: A systematic review with meta-analysis |
title_full | Factors associated with false negative interferon-γ release assay results in patients with tuberculosis: A systematic review with meta-analysis |
title_fullStr | Factors associated with false negative interferon-γ release assay results in patients with tuberculosis: A systematic review with meta-analysis |
title_full_unstemmed | Factors associated with false negative interferon-γ release assay results in patients with tuberculosis: A systematic review with meta-analysis |
title_short | Factors associated with false negative interferon-γ release assay results in patients with tuberculosis: A systematic review with meta-analysis |
title_sort | factors associated with false negative interferon-γ release assay results in patients with tuberculosis: a systematic review with meta-analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994686/ https://www.ncbi.nlm.nih.gov/pubmed/32005930 http://dx.doi.org/10.1038/s41598-020-58459-9 |
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