Factors associated with false negative interferon-γ release assay results in patients with tuberculosis: A systematic review with meta-analysis

Which factors are related to false negative results of the interferon-γ release assay (IGRA) is unclear. This systematic review described the risk factors associated with false negative IGRA results. Two authors independently identified studies designed to evaluate risk factors for false negative IG...

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Autores principales: Yamasue, Mari, Komiya, Kosaku, Usagawa, Yuko, Umeki, Kenji, Nureki, Shin-ichi, Ando, Masaru, Hiramatsu, Kazufumi, Nagai, Hideaki, Kadota, Jun-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994686/
https://www.ncbi.nlm.nih.gov/pubmed/32005930
http://dx.doi.org/10.1038/s41598-020-58459-9
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author Yamasue, Mari
Komiya, Kosaku
Usagawa, Yuko
Umeki, Kenji
Nureki, Shin-ichi
Ando, Masaru
Hiramatsu, Kazufumi
Nagai, Hideaki
Kadota, Jun-ichi
author_facet Yamasue, Mari
Komiya, Kosaku
Usagawa, Yuko
Umeki, Kenji
Nureki, Shin-ichi
Ando, Masaru
Hiramatsu, Kazufumi
Nagai, Hideaki
Kadota, Jun-ichi
author_sort Yamasue, Mari
collection PubMed
description Which factors are related to false negative results of the interferon-γ release assay (IGRA) is unclear. This systematic review described the risk factors associated with false negative IGRA results. Two authors independently identified studies designed to evaluate risk factors for false negative IGRA results from PubMed, the Cochrane Register of Control Trial database, and EMBASE, accessed on October 22, 2018. Meta-analyses were conducted with random-effect models, and heterogeneity was calculated with the I(2) method. Of 1,377 titles and abstracts screened, 47 full texts were selected for review, and we finally included 17 studies in this systematic review. The most commonly studied risk factor (14 studies) was advanced age, followed by low peripheral lymphocyte counts (7 studies), and these factors were associated with false negative results even with different tuberculosis incidences (pooled odds ratio 2.06; 95% CI, 1.68–2.52 in advanced age and 2.68; 95% CI, 2.00–3.61 in low peripheral lymphocyte counts). Advanced age and low peripheral lymphocyte counts may be common risk factors for false negative IGRA results, suggesting that people with these factors need to be carefully followed, even if they have negative IGRA results.
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spelling pubmed-69946862020-02-06 Factors associated with false negative interferon-γ release assay results in patients with tuberculosis: A systematic review with meta-analysis Yamasue, Mari Komiya, Kosaku Usagawa, Yuko Umeki, Kenji Nureki, Shin-ichi Ando, Masaru Hiramatsu, Kazufumi Nagai, Hideaki Kadota, Jun-ichi Sci Rep Article Which factors are related to false negative results of the interferon-γ release assay (IGRA) is unclear. This systematic review described the risk factors associated with false negative IGRA results. Two authors independently identified studies designed to evaluate risk factors for false negative IGRA results from PubMed, the Cochrane Register of Control Trial database, and EMBASE, accessed on October 22, 2018. Meta-analyses were conducted with random-effect models, and heterogeneity was calculated with the I(2) method. Of 1,377 titles and abstracts screened, 47 full texts were selected for review, and we finally included 17 studies in this systematic review. The most commonly studied risk factor (14 studies) was advanced age, followed by low peripheral lymphocyte counts (7 studies), and these factors were associated with false negative results even with different tuberculosis incidences (pooled odds ratio 2.06; 95% CI, 1.68–2.52 in advanced age and 2.68; 95% CI, 2.00–3.61 in low peripheral lymphocyte counts). Advanced age and low peripheral lymphocyte counts may be common risk factors for false negative IGRA results, suggesting that people with these factors need to be carefully followed, even if they have negative IGRA results. Nature Publishing Group UK 2020-01-31 /pmc/articles/PMC6994686/ /pubmed/32005930 http://dx.doi.org/10.1038/s41598-020-58459-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Yamasue, Mari
Komiya, Kosaku
Usagawa, Yuko
Umeki, Kenji
Nureki, Shin-ichi
Ando, Masaru
Hiramatsu, Kazufumi
Nagai, Hideaki
Kadota, Jun-ichi
Factors associated with false negative interferon-γ release assay results in patients with tuberculosis: A systematic review with meta-analysis
title Factors associated with false negative interferon-γ release assay results in patients with tuberculosis: A systematic review with meta-analysis
title_full Factors associated with false negative interferon-γ release assay results in patients with tuberculosis: A systematic review with meta-analysis
title_fullStr Factors associated with false negative interferon-γ release assay results in patients with tuberculosis: A systematic review with meta-analysis
title_full_unstemmed Factors associated with false negative interferon-γ release assay results in patients with tuberculosis: A systematic review with meta-analysis
title_short Factors associated with false negative interferon-γ release assay results in patients with tuberculosis: A systematic review with meta-analysis
title_sort factors associated with false negative interferon-γ release assay results in patients with tuberculosis: a systematic review with meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994686/
https://www.ncbi.nlm.nih.gov/pubmed/32005930
http://dx.doi.org/10.1038/s41598-020-58459-9
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