Ablation of Bscl2/seipin in hepatocytes does not cause metabolic dysfunction in congenital generalised lipodystrophy

Mutations affecting the BSCL2 gene cause the most severe form of congenital generalised lipodystrophy (CGL). Affected individuals develop severe metabolic complications including diabetes and hepatic steatosis. Bscl2-deficient mice almost entirely reproduce the CGL phenotype. Adipose tissue-specific...

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Detalles Bibliográficos
Autores principales: Mcilroy, George D., Mitchell, Sharon E., Han, Weiping, Delibegović, Mirela, Rochford, Justin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994952/
https://www.ncbi.nlm.nih.gov/pubmed/31848133
http://dx.doi.org/10.1242/dmm.042655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994952/
https://www.ncbi.nlm.nih.gov/pubmed/31848133
http://dx.doi.org/10.1242/dmm.042655

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