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Establishment and validation of an endoplasmic reticulum stress reporter to monitor zebrafish ATF6 activity in development and disease

Induction of endoplasmic reticulum (ER) stress is associated with diverse developmental and degenerative diseases. Modified ER homeostasis causes activation of conserved stress pathways at the ER called the unfolded protein response (UPR). ATF6 is a transcription factor activated during ER stress as...

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Detalles Bibliográficos
Autores principales: Clark, Eric M., Nonarath, Hannah J. T., Bostrom, Jonathan R., Link, Brian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994954/
https://www.ncbi.nlm.nih.gov/pubmed/31852729
http://dx.doi.org/10.1242/dmm.041426