Missing regions within the molecular architecture of human fibrin clots structurally resolved by XL-MS and integrative structural modeling

Upon activation, fibrinogen forms large fibrin biopolymers that coalesce into clots which assist in wound healing. Limited insights into their molecular architecture, due to the sheer size and the insoluble character of fibrin clots, have restricted our ability to develop novel treatments for clotti...

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Detalles Bibliográficos
Autores principales: Klykov, Oleg, van der Zwaan, Carmen, Heck, Albert J. R., Meijer, Alexander B., Scheltema, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995014/
https://www.ncbi.nlm.nih.gov/pubmed/31924745
http://dx.doi.org/10.1073/pnas.1911785117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995014/
https://www.ncbi.nlm.nih.gov/pubmed/31924745
http://dx.doi.org/10.1073/pnas.1911785117

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