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Identification of functional regulatory elements in the human genome using pooled CRISPR screens

BACKGROUND: Genome-scale pooled CRISPR screens are powerful tools for identifying genetic dependencies across varied cellular processes. The vast majority of CRISPR screens reported to date have focused exclusively on the perturbation of protein-coding gene function. However, protein-coding genes co...

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Detalles Bibliográficos
Autores principales: Borys, Samantha M., Younger, Scott T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995077/
https://www.ncbi.nlm.nih.gov/pubmed/32005150
http://dx.doi.org/10.1186/s12864-020-6497-0