DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations

DNA damage is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). However, relationships between DNA damage accumulation, DNA damage response (DDR), and upper and lower motor neuron vulnerability in human ALS are unclear; furthermore, it is unknown whether epigenetic silencing of...

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Detalles Bibliográficos
Autores principales: Kim, Byung Woo, Jeong, Ye Eun, Wong, Margaret, Martin, Lee J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995159/
https://www.ncbi.nlm.nih.gov/pubmed/32005289
http://dx.doi.org/10.1186/s40478-019-0874-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995159/
https://www.ncbi.nlm.nih.gov/pubmed/32005289
http://dx.doi.org/10.1186/s40478-019-0874-4

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