Targeting the NAD(+) salvage pathway suppresses APC mutation-driven colorectal cancer growth and Wnt/β-catenin signaling via increasing Axin level

BACKGROUND: The role and mechanism of the nicotinamide adenine dinucleotide (NAD(+)) salvage pathway in cancer cell proliferation is poorly understood. Nicotinamide phosphoribosyltransferase (NAMPT), which converts nicotinamide into NAD(+), is the rate-limiting enzyme in the NAD(+) salvage pathway....

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Detalles Bibliográficos
Autores principales: Ye, Chenyang, Qi, Lina, Li, Xiaofen, Wang, Ji, Yu, Jiekai, Zhou, Biting, Guo, Cheng, Chen, Jiani, Zheng, Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995173/
https://www.ncbi.nlm.nih.gov/pubmed/32005247
http://dx.doi.org/10.1186/s12964-020-0513-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995173/
https://www.ncbi.nlm.nih.gov/pubmed/32005247
http://dx.doi.org/10.1186/s12964-020-0513-5

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