Protocol for evaluating the abilities of diverse nitroaromatic prodrug metabolites to exit a model Gram negative bacterial vector

Bacterial-directed enzyme-prodrug therapy (BDEPT) uses tumour-tropic bacteria armed with a genetically-encoded prodrug-converting enzyme to sensitise tumours to a systemically-administered prodrug. A strong bystander effect (i.e., efficient bacteria-to-tumour transfer of activated prodrug metabolite...

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Detalles Bibliográficos
Autores principales: Chan-Hyams, Jasmine V.E., Ackerley, David F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Pharmacology, Toxicology and Pharmaceutical Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995258/
https://www.ncbi.nlm.nih.gov/pubmed/32021829
http://dx.doi.org/10.1016/j.mex.2020.100797

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995258/
https://www.ncbi.nlm.nih.gov/pubmed/32021829
http://dx.doi.org/10.1016/j.mex.2020.100797

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