Critical Factors in Human Antizymes that Determine the Differential Binding, Inhibition, and Degradation of Human Ornithine Decarboxylase

Antizyme (AZ) is a protein that negatively regulates ornithine decarboxylase (ODC). AZ achieves this inhibition by binding to ODC to produce AZ-ODC heterodimers, abolishing enzyme activity and targeting ODC for degradation by the 26S proteasome. In this study, we focused on the biomolecular interact...

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Detalles Bibliográficos
Autores principales: Hsieh, Ju-Yi, Liu, Yen-Chin, Cheng, I-Ting, Lee, Chu-Ju, Wang, Yu-Hsuan, Fang, Yi-Shiuan, Liu, Yi-Liang, Liu, Guang-Yaw, Hung, Hui-Chih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995573/
https://www.ncbi.nlm.nih.gov/pubmed/31842334
http://dx.doi.org/10.3390/biom9120864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995573/
https://www.ncbi.nlm.nih.gov/pubmed/31842334
http://dx.doi.org/10.3390/biom9120864

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