Evolutionary Analyses of Sequence and Structure Space Unravel the Structural Facets of SOD1

Superoxide dismutase (SOD) is the primary enzyme of the cellular antioxidant defense cascade. Misfolding, concomitant oligomerization, and higher order aggregation of human cytosolic SOD are linked to amyotrophic lateral sclerosis (ALS). Although, with two metal ion cofactors SOD1 is extremely robus...

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Detalles Bibliográficos
Autores principales: Chowdhury, Sourav, Sanyal, Dwipanjan, Sen, Sagnik, Uversky, Vladimir N., Maulik, Ujjwal, Chattopadhyay, Krishnananda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995586/
https://www.ncbi.nlm.nih.gov/pubmed/31817166
http://dx.doi.org/10.3390/biom9120826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995586/
https://www.ncbi.nlm.nih.gov/pubmed/31817166
http://dx.doi.org/10.3390/biom9120826

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