Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B

The single‐stranded DNA cytosine deaminase APOBEC3B (A3B) functions in innate immunity against viruses, but it is also strongly implicated in eliciting mutations in cancer genomes. Because of the critical role of A3B in promoting virus and tumor evolution, small molecule inhibitors are desirable. Ho...

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Detalles Bibliográficos
Autores principales: Shi, Ke, Demir, Özlem, Carpenter, Michael A., Banerjee, Surajit, Harki, Daniel A., Amaro, Rommie E., Harris, Reuben S., Aihara, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996314/
https://www.ncbi.nlm.nih.gov/pubmed/32123856
http://dx.doi.org/10.1096/fba.2019-00068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996314/
https://www.ncbi.nlm.nih.gov/pubmed/32123856
http://dx.doi.org/10.1096/fba.2019-00068

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