Drysdalin, an antagonist of nicotinic acetylcholine receptors highlights the importance of functional rather than structural conservation of amino acid residues

Snake venom neurotoxins are potent antagonists of nicotinic acetylcholine receptors (nAChRs). Here, we describe a novel member of class 3c long‐chain neurotoxin drysdalin from the venom of Drysdalia coronoides. Drysdalin lacks three of the eight conserved classical functional residues critical for n...

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Detalles Bibliográficos
Autores principales: Chandna, Ritu, Tae, Han‐Shen, Seymour, Victoria A. L., Chathrath, Shifali, Adams, David J., Kini, R. Manjunatha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996315/
https://www.ncbi.nlm.nih.gov/pubmed/32123825
http://dx.doi.org/10.1096/fba.1027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996315/
https://www.ncbi.nlm.nih.gov/pubmed/32123825
http://dx.doi.org/10.1096/fba.1027

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