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Single-residue physicochemical characteristics kinetically partition membrane protein self-assembly and aggregation
Ninety-five percent of all transmembrane proteins exist in kinetically trapped aggregation-prone states that have been directly linked to neurodegenerative diseases. Interestingly, the primary sequence almost invariably avoids off-pathway aggregate formation, by folding reliably into its native, the...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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American Society for Biochemistry and Molecular Biology
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996891/ https://www.ncbi.nlm.nih.gov/pubmed/31844019 http://dx.doi.org/10.1074/jbc.RA119.011342 |