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Single-residue physicochemical characteristics kinetically partition membrane protein self-assembly and aggregation

Ninety-five percent of all transmembrane proteins exist in kinetically trapped aggregation-prone states that have been directly linked to neurodegenerative diseases. Interestingly, the primary sequence almost invariably avoids off-pathway aggregate formation, by folding reliably into its native, the...

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Detalles Bibliográficos
Autores principales:	Gupta, Ankit, Mahalakshmi, Radhakrishnan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996891/ https://www.ncbi.nlm.nih.gov/pubmed/31844019 http://dx.doi.org/10.1074/jbc.RA119.011342

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