Cdc7 activates replication checkpoint by phosphorylating the Chk1-binding domain of Claspin in human cells

Replication checkpoint is essential for maintaining genome integrity in response to various replication stresses as well as during the normal growth. The evolutionally conserved ATR-Claspin-Chk1 pathway is induced during replication checkpoint activation. Cdc7 kinase, required for initiation of DNA...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Chi-Chun, Kato, Hiroyuki, Shindo, Mayumi, Masai, Hisao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996922/
https://www.ncbi.nlm.nih.gov/pubmed/31889509
http://dx.doi.org/10.7554/eLife.50796

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996922/
https://www.ncbi.nlm.nih.gov/pubmed/31889509
http://dx.doi.org/10.7554/eLife.50796

Ejemplares similares