Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR

Coupling of endoplasmic reticulum (ER) stress to dimerisation-dependent activation of the UPR transducer IRE1 is incompletely understood. Whilst the luminal co-chaperone ERdj4 promotes a complex between the Hsp70 BiP and IRE1’s stress-sensing luminal domain (IRE1(LD)) that favours the latter’s monom...

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Detalles Bibliográficos
Autores principales: Amin-Wetzel, Niko, Neidhardt, Lisa, Yan, Yahui, Mayer, Matthias P, Ron, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996924/
https://www.ncbi.nlm.nih.gov/pubmed/31873072
http://dx.doi.org/10.7554/eLife.50793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996924/
https://www.ncbi.nlm.nih.gov/pubmed/31873072
http://dx.doi.org/10.7554/eLife.50793

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