Cargando…

Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR

Coupling of endoplasmic reticulum (ER) stress to dimerisation-dependent activation of the UPR transducer IRE1 is incompletely understood. Whilst the luminal co-chaperone ERdj4 promotes a complex between the Hsp70 BiP and IRE1’s stress-sensing luminal domain (IRE1(LD)) that favours the latter’s monom...

Descripción completa

Detalles Bibliográficos
Autores principales:	Amin-Wetzel, Niko, Neidhardt, Lisa, Yan, Yahui, Mayer, Matthias P, Ron, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996924/ https://www.ncbi.nlm.nih.gov/pubmed/31873072 http://dx.doi.org/10.7554/eLife.50793

Ejemplares similares

Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes
por: Preissler, Steffen, et al.
Publicado: (2020)

UPR proteins IRE1 and PERK switch BiP from chaperone to ER stress sensor
por: Kopp, Megan C, et al.
Publicado: (2019)

A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response
por: Amin-Wetzel, Niko, et al.
Publicado: (2017)

Essential Roles of the Kar2/BiP Molecular Chaperone Downstream of the UPR Pathway in Cryptococcus neoformans
por: Jung, Kwang-Woo, et al.
Publicado: (2013)

The Role of BiP and the IRE1α–XBP1 Axis in Rhabdomyosarcoma Pathology
por: Aghaei, Mahmoud, et al.
Publicado: (2021)

A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1
por: Kimata, Yukio, et al.
Publicado: (2004)

An oligomeric state‐dependent switch in the ER enzyme FICD regulates AMPylation and deAMPylation of BiP
por: Perera, Luke A, et al.
Publicado: (2019)

In vitro FRET analysis of IRE1 and BiP association and dissociation upon endoplasmic reticulum stress
por: Kopp, Megan C, et al.
Publicado: (2018)

Regulation of PERK Signaling and Leukemic Cell Survival by a Novel Cytosolic Isoform of the UPR Regulator GRP78/BiP
por: Ni, Min, et al.
Publicado: (2009)

BiP Binding to the ER-Stress Sensor Ire1 Tunes the Homeostatic Behavior of the Unfolded Protein Response
por: Pincus, David, et al.
Publicado: (2010)

UPR Signal Activation by Luminal Sensor Domains
por: Carrara, Marta, et al.
Publicado: (2013)

MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP
por: Yan, Yahui, et al.
Publicado: (2019)

Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase
por: Chawla, Aditi, et al.
Publicado: (2011)

Cab45S inhibits the ER stress-induced IRE1-JNK pathway and apoptosis via GRP78/BiP
por: Chen, L, et al.
Publicado: (2014)

A UPR-independent infection-specific role for a BiP/GRP78 protein in the control of antimicrobial peptide expression in C. elegans epidermis
por: Couillault, Carole, et al.
Publicado: (2012)

BiP chaperones ER entry
por: LeBrasseur, Nicole
Publicado: (2005)

A role for the ribosome-associated complex in activation of the IRE1 branch of UPR
por: Wu, I-Hui, et al.
Publicado: (2021)

It's a chaperone … it's a gatekeeper … it's BiP
por: Dove, Alan W.
Publicado: (2002)

A big BiP on the radar screen
por: Powell, Kendall
Publicado: (2005)

BiP prevents rod opsin aggregation
por: Athanasiou, Dimitra, et al.
Publicado: (2012)

BiP Negatively Affects Ricin Transport
por: Gregers, Tone F., et al.
Publicado: (2013)

Emodin-Induced Oxidative Inhibition of Mitochondrial Function Assists BiP/IRE1α/CHOP Signaling-Mediated ER-Related Apoptosis
por: Qiu, Li-zhen, et al.
Publicado: (2021)

AtIRE1C, an unconventional isoform of the UPR master regulator AtIRE1, is functionally associated with AtIRE1B in Arabidopsis gametogenesis
por: Pu, Yunting, et al.
Publicado: (2019)

Ratiometric sensing of BiP-client versus BiP levels by the unfolded protein response determines its signaling amplitude
por: Bakunts, Anush, et al.
Publicado: (2017)

The UPR Branch IRE1-bZIP60 in Plants Plays an Essential Role in Viral Infection and Is Complementary to the Only UPR Pathway in Yeast
por: Zhang, Lingrui, et al.
Publicado: (2015)

ATP-Competitive Partial Antagonists of IRE1α’s RNase Segregate Outputs of the UPR
por: Feldman, Hannah C., et al.
Publicado: (2021)

Human cDC1s display constitutive activation of the UPR sensor IRE1
por: García‐González, Paulina, et al.
Publicado: (2022)

The Lumenal Domain of Sec63p Stimulates the ATPase Activity of BiP and Mediates BiP Recruitment to the Translocon in Saccharomyces cerevisiae
por: Corsi, Ann K., et al.
Publicado: (1997)

Detection of autoantibodies to citrullinated BiP in rheumatoid arthritis patients and pro-inflammatory role of citrullinated BiP in collagen-induced arthritis
por: Shoda, Hirofumi, et al.
Publicado: (2011)

GPNMB Induces BiP Expression by Enhancing Splicing of BiP Pre-mRNA during the Endoplasmic Reticulum Stress Response
por: Noda, Yasuhiro, et al.
Publicado: (2017)

Genome-wide identification and characterization of Solanum tuberosum BiP genes reveal the role of the promoter architecture in BiP gene diversity
por: Herath, Venura, et al.
Publicado: (2020)

AMPylation targets the rate-limiting step of BiP’s ATPase cycle for its functional inactivation
por: Preissler, Steffen, et al.
Publicado: (2017)

Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein C(H)1 to initiate ER stress signaling
por: Carrara, Marta, et al.
Publicado: (2015)

Destabilisation of dimeric 14-3-3 proteins as a novel approach to anti-cancer therapeutics
por: Woodcock, Joanna M., et al.
Publicado: (2015)

The In Vivo Association of BiP with Newly Synthesized Proteins Is Dependent on the Rate and Stability of Folding and Not Simply on the Presence of Sequences That Can Bind to BiP
por: Hellman, Rachel, et al.
Publicado: (1999)

The ER luminal binding protein (BiP) mediates an increase in drought tolerance in soybean and delays drought-induced leaf senescence in soybean and tobacco
por: Valente, Maria Anete S., et al.
Publicado: (2009)

BiP induces IL-4-dependent regulatory cells
por: Brownlie, R, et al.
Publicado: (2005)

BiP Clustering Facilitates Protein Folding in the Endoplasmic Reticulum
por: Griesemer, Marc, et al.
Publicado: (2014)

Inadequate BiP availability defines endoplasmic reticulum stress
por: Vitale, Milena, et al.
Publicado: (2019)

Preservation of circadian rhythms by the protein folding chaperone, BiP
por: Pickard, Adam, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ipp86o4hsg7bqlg31d1thrcaj4