Maf1‐dependent transcriptional regulation of tRNAs prevents genomic instability and is associated with extended lifespan

Maf1 is the master repressor of RNA polymerase III responsible for transcription of tRNAs and 5S rRNAs. Maf1 is negatively regulated via phosphorylation by the mTOR pathway, which governs protein synthesis, growth control, and lifespan regulation in response to nutrient availability. Inhibiting the...

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Detalles Bibliográficos
Autores principales: Shetty, Mihir, Noguchi, Chiaki, Wilson, Sydney, Martinez, Esteban, Shiozaki, Kazuhiro, Sell, Christian, Mell, Joshua Chang, Noguchi, Eishi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996946/
https://www.ncbi.nlm.nih.gov/pubmed/31833215
http://dx.doi.org/10.1111/acel.13068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996946/
https://www.ncbi.nlm.nih.gov/pubmed/31833215
http://dx.doi.org/10.1111/acel.13068

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