Mitochondrial mass governs the extent of human T cell senescence

The susceptibility of human CD4(+) and CD8(+) T cells to senesce differs, with CD8(+) T cells acquiring an immunosenescent phenotype faster than the CD4(+) T cell compartment. We show here that it is the inherent difference in mitochondrial content that drives this phenotype, with senescent human CD...

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Detalles Bibliográficos
Autores principales: Callender, Lauren A., Carroll, Elizabeth C., Bober, Emilia A., Akbar, Arne N., Solito, Egle, Henson, Sian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996952/
https://www.ncbi.nlm.nih.gov/pubmed/31788930
http://dx.doi.org/10.1111/acel.13067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996952/
https://www.ncbi.nlm.nih.gov/pubmed/31788930
http://dx.doi.org/10.1111/acel.13067

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