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Mitochondrial mass governs the extent of human T cell senescence
The susceptibility of human CD4(+) and CD8(+) T cells to senesce differs, with CD8(+) T cells acquiring an immunosenescent phenotype faster than the CD4(+) T cell compartment. We show here that it is the inherent difference in mitochondrial content that drives this phenotype, with senescent human CD...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996952/ https://www.ncbi.nlm.nih.gov/pubmed/31788930 http://dx.doi.org/10.1111/acel.13067 |