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EGFR exon 19‐deletion aberrantly regulate ERCC1 expression that may partly impaired DNA damage repair ability in non‐small cell lung cancer

BACKGROUND: Epidermal growth factor receptor (EGFR) activating mutations are usually associated with DNA damage repair (DDR) deficiency. However, the precise mechanism has remained elusive. In this study, we aimed to investigate whether EGFR exon 19 deletion mutation downstream signals contributed t...

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Detalles Bibliográficos
Autores principales: Zhang, Linlin, Pradhan, Barun, Guo, Lili, Meng, Fanlu, Zhong, Diansheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996978/
https://www.ncbi.nlm.nih.gov/pubmed/31875360
http://dx.doi.org/10.1111/1759-7714.13253