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A micro-XRT image analysis and machine learning methodology for the characterisation of multi-particulate capsule formulations

The application of X-ray microtomography for quantitative structural analysis of pharmaceutical multi-particulate systems was demonstrated for commercial capsules, each containing approximately 300 formulated ibuprofen pellets. The implementation of a marker-supported watershed transformation enable...

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Detalles Bibliográficos
Autores principales: Doerr, Frederik J.S., Florence, Alastair J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997304/
https://www.ncbi.nlm.nih.gov/pubmed/32025658
http://dx.doi.org/10.1016/j.ijpx.2020.100041