A20 targets PFKL and glycolysis to inhibit the progression of hepatocellular carcinoma

Abnormal expression of the E3 ubiquitin ligase A20 has been found in some malignant cancers, including hepatocellular carcinoma (HCC). Here, we discovered that A20 is an E3 ubiquitin ligase for phosphofructokinase, liver type (PFKL) in HCC A20 interacts with PFKL and promotes its degradation, theref...

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Detalles Bibliográficos
Autores principales: Feng, Yilu, Zhang, Ye, Cai, Yi, Liu, Ruijie, Lu, Miaolong, Li, Tangzhiming, Fu, Ying, Guo, Ming, Huang, Huichao, Ou, Yifu, Chen, Yongheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997366/
https://www.ncbi.nlm.nih.gov/pubmed/32015333
http://dx.doi.org/10.1038/s41419-020-2278-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997366/
https://www.ncbi.nlm.nih.gov/pubmed/32015333
http://dx.doi.org/10.1038/s41419-020-2278-6

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