SCF(β-TrCP)-mediated degradation of TOP2β promotes cancer cell survival in response to chemotherapeutic drugs targeting topoisomerase II

Topoisomerase II (TOP2)-targeting anticancer chemotherapeutic drugs, termed TOP2 poisons, are widely used and effective in the clinic by stabilizing TOP2-DNA covalent complexes to induce DNA double-strand breaks (DSBs) and ultimately, cause cell death. The stabilized TOP2-DNA complex is known to be...

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Detalles Bibliográficos
Autores principales: Shu, Jianfeng, Cui, Danrui, Ma, Ying, Xiong, Xiufang, Sun, Yi, Zhao, Yongchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997367/
https://www.ncbi.nlm.nih.gov/pubmed/32015321
http://dx.doi.org/10.1038/s41389-020-0196-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997367/
https://www.ncbi.nlm.nih.gov/pubmed/32015321
http://dx.doi.org/10.1038/s41389-020-0196-1

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