A 4-gene signature from histologically normal surgical margins predicts local recurrence in patients with oral carcinoma: clinical validation

Prognostic biomarkers for recurrence of Oral Squamous Cell Carcinoma (OSCC) are urgently needed. We aimed to independently validate a 4-gene expression signature (MMP1, COL4A1, P4HA2, THBS2) predictive of OSCC recurrence risk. Gene expression was measured using Nanostring nCounter(®) in 245 histolog...

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Detalles Bibliográficos
Autores principales: Reis, Patricia P., Tokar, Tomas, Goswami, Rashmi S., Xuan, Yali, Sukhai, Mahadeo, Seneda, Ana Laura, Móz, Luis E. S., Perez-Ordonez, Bayardo, Simpson, Colleen, Goldstein, David, Brown, Dale, Gilbert, Ralph, Gullane, Patrick, Irish, Jonathan, Jurisica, Igor, Kamel-Reid, Suzanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997450/
https://www.ncbi.nlm.nih.gov/pubmed/32015424
http://dx.doi.org/10.1038/s41598-020-58688-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997450/
https://www.ncbi.nlm.nih.gov/pubmed/32015424
http://dx.doi.org/10.1038/s41598-020-58688-y

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