HIF-1α Regulates Glucocorticoid-Induced Osteoporosis Through PDK1/AKT/mTOR Signaling Pathway

Long-term and high dose glucocorticoid treatment can cause decreased viability and function of osteoblasts, which leads to osteoporosis and osteonecrosis. In this study, we investigated the role and mechanism of action of HIF-1α in glucocorticoid-induced osteogenic inhibition in MC3T3-E1 cells. Our...

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Detalles Bibliográficos
Autores principales: Xu, Wen-Ning, Zheng, Huo-Liang, Yang, Run-Ze, Jiang, Lei-Sheng, Jiang, Sheng-Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997475/
https://www.ncbi.nlm.nih.gov/pubmed/32047474
http://dx.doi.org/10.3389/fendo.2019.00922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997475/
https://www.ncbi.nlm.nih.gov/pubmed/32047474
http://dx.doi.org/10.3389/fendo.2019.00922

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