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A nematode sterol C4α-methyltransferase catalyzes a new methylation reaction responsible for sterol diversity

Primitive sterol evolution plays an important role in fossil record interpretation and offers potential therapeutic avenues for human disease resulting from nematode infections. Recognizing that C4-methyl stenol products [8(14)-lophenol] can be synthesized in bacteria while C4-methyl stanol products...

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Detalles Bibliográficos
Autores principales: Zhou, Wenxu, Fisher, Paxtyn M., Vanderloop, Boden H., Shen, Yun, Shi, Huazhong, Maldonado, Adrian J., Leaver, David J., Nes, W. David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997595/
https://www.ncbi.nlm.nih.gov/pubmed/31548366
http://dx.doi.org/10.1194/jlr.RA119000317