Activation of spinal alpha-7 nicotinic acetylcholine receptor shortens the duration of remifentanil-induced postoperative hyperalgesia by upregulating KCC2 in the spinal dorsal horn in rats

BACKGROUND: Accumulating evidence has shown that the signal from spinal brain-derived neurotrophic factor/tyrosine receptor kinase B-K(+)-Cl(−) cotransporter-2 plays a critical role in the process of pain hypersensitivity. The activation of alpha-7 nicotinic acetylcholine receptors could have an ana...

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Detalles Bibliográficos
Autores principales: Gu, Wei, Zhang, Wei, Lei, Yishan, Cui, Yin, Chu, Shuaishuai, Gu, Xiaoping, Ma, Zhengliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997724/
https://www.ncbi.nlm.nih.gov/pubmed/28425312
http://dx.doi.org/10.1177/1744806917704769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997724/
https://www.ncbi.nlm.nih.gov/pubmed/28425312
http://dx.doi.org/10.1177/1744806917704769

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