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Activation of spinal alpha-7 nicotinic acetylcholine receptor shortens the duration of remifentanil-induced postoperative hyperalgesia by upregulating KCC2 in the spinal dorsal horn in rats

BACKGROUND: Accumulating evidence has shown that the signal from spinal brain-derived neurotrophic factor/tyrosine receptor kinase B-K(+)-Cl(−) cotransporter-2 plays a critical role in the process of pain hypersensitivity. The activation of alpha-7 nicotinic acetylcholine receptors could have an ana...

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Detalles Bibliográficos
Autores principales:	Gu, Wei, Zhang, Wei, Lei, Yishan, Cui, Yin, Chu, Shuaishuai, Gu, Xiaoping, Ma, Zhengliang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997724/ https://www.ncbi.nlm.nih.gov/pubmed/28425312 http://dx.doi.org/10.1177/1744806917704769

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