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Differences Between Human and Murine Tau at the N-terminal End

Human tauopathies, such as Alzheimer’s disease (AD), have been widely studied in transgenic mice overexpressing human tau in the brain. The longest brain isoforms of Tau in mice and humans show 89% amino acid identity; however, the expression of the isoforms of this protein in the adult brain of the...

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Autores principales: Hernández, Félix, Merchán-Rubira, Jesús, Vallés-Saiz, Laura, Rodríguez-Matellán, Alberto, Avila, Jesús
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999090/
https://www.ncbi.nlm.nih.gov/pubmed/32063841
http://dx.doi.org/10.3389/fnagi.2020.00011
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author Hernández, Félix
Merchán-Rubira, Jesús
Vallés-Saiz, Laura
Rodríguez-Matellán, Alberto
Avila, Jesús
author_facet Hernández, Félix
Merchán-Rubira, Jesús
Vallés-Saiz, Laura
Rodríguez-Matellán, Alberto
Avila, Jesús
author_sort Hernández, Félix
collection PubMed
description Human tauopathies, such as Alzheimer’s disease (AD), have been widely studied in transgenic mice overexpressing human tau in the brain. The longest brain isoforms of Tau in mice and humans show 89% amino acid identity; however, the expression of the isoforms of this protein in the adult brain of the two species differs. Tau 3R isoforms are not present in adult mice. In contrast, the adult human brain contains Tau 3R and also Tau 4R isoforms. In addition, the N-terminal sequence of Tau protein in mice and humans differs, a Tau peptide (residues 17–28) being present in the latter but absent in the former. Here we review the main published data on this N-terminal sequence that suggests that human and mouse Tau proteins interact with different endogenous proteins and also show distinct secretion patterns.
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spelling pubmed-69990902020-02-14 Differences Between Human and Murine Tau at the N-terminal End Hernández, Félix Merchán-Rubira, Jesús Vallés-Saiz, Laura Rodríguez-Matellán, Alberto Avila, Jesús Front Aging Neurosci Neuroscience Human tauopathies, such as Alzheimer’s disease (AD), have been widely studied in transgenic mice overexpressing human tau in the brain. The longest brain isoforms of Tau in mice and humans show 89% amino acid identity; however, the expression of the isoforms of this protein in the adult brain of the two species differs. Tau 3R isoforms are not present in adult mice. In contrast, the adult human brain contains Tau 3R and also Tau 4R isoforms. In addition, the N-terminal sequence of Tau protein in mice and humans differs, a Tau peptide (residues 17–28) being present in the latter but absent in the former. Here we review the main published data on this N-terminal sequence that suggests that human and mouse Tau proteins interact with different endogenous proteins and also show distinct secretion patterns. Frontiers Media S.A. 2020-01-28 /pmc/articles/PMC6999090/ /pubmed/32063841 http://dx.doi.org/10.3389/fnagi.2020.00011 Text en Copyright © 2020 Hernández, Merchán-Rubira, Vallés-Saiz, Rodríguez-Matellán and Avila. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Hernández, Félix
Merchán-Rubira, Jesús
Vallés-Saiz, Laura
Rodríguez-Matellán, Alberto
Avila, Jesús
Differences Between Human and Murine Tau at the N-terminal End
title Differences Between Human and Murine Tau at the N-terminal End
title_full Differences Between Human and Murine Tau at the N-terminal End
title_fullStr Differences Between Human and Murine Tau at the N-terminal End
title_full_unstemmed Differences Between Human and Murine Tau at the N-terminal End
title_short Differences Between Human and Murine Tau at the N-terminal End
title_sort differences between human and murine tau at the n-terminal end
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999090/
https://www.ncbi.nlm.nih.gov/pubmed/32063841
http://dx.doi.org/10.3389/fnagi.2020.00011
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