PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma

Lysosomal membrane permeabilization (LMP) is observed under many pathological conditions, leading to cellular dysfunction and death. However, the mechanisms by which lysosomal membranes become leaky in vivo are not clear. Our data demonstrate that LMP occurs in neurons following controlled cortical...

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Detalles Bibliográficos
Autores principales: Sarkar, Chinmoy, Jones, Jace W., Hegdekar, Nivedita, Thayer, Julia A., Kumar, Alok, Faden, Alan I., Kane, Maureen A., Lipinski, Marta M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999646/
https://www.ncbi.nlm.nih.gov/pubmed/31238788
http://dx.doi.org/10.1080/15548627.2019.1628538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999646/
https://www.ncbi.nlm.nih.gov/pubmed/31238788
http://dx.doi.org/10.1080/15548627.2019.1628538

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