Checkpoint molecules coordinately restrain hyperactivated effector T cells in the tumor microenvironment

The immune checkpoint blockade (ICB) immunotherapy has prolonged overall survival for cancer patients but the response rates are low. The resistance to ICB is likely due to compensatory upregulation of additional immune inhibitory molecules. In this study, we first systematically examined Tim-3 expr...

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Detalles Bibliográficos
Autores principales: Yang, Min, Du, Wenwen, Yi, Lixian, Wu, Shaoxian, He, Chunyan, Zhai, Wensi, Yue, Cuihua, Sun, Runzi, Menk, Ashley V., Delgoffe, Greg M., Jiang, Jingting, Lu, Binfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999836/
https://www.ncbi.nlm.nih.gov/pubmed/32076578
http://dx.doi.org/10.1080/2162402X.2019.1708064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999836/
https://www.ncbi.nlm.nih.gov/pubmed/32076578
http://dx.doi.org/10.1080/2162402X.2019.1708064

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