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Kinetics of α-synuclein prions preceding neuropathological inclusions in multiple system atrophy

Multiple system atrophy (MSA), a progressive neurodegenerative disease characterized by autonomic dysfunction and motor impairment, is caused by the self-templated misfolding of the protein α-synuclein. With no treatment currently available, we sought to characterize the spread of α-synuclein in a t...

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Detalles Bibliográficos
Autores principales:	Woerman, Amanda L., Patel, Smita, Kazmi, Sabeen A., Oehler, Abby, Lee, Jisoo, Mordes, Daniel A., Olson, Steven H., Prusiner, Stanley B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999861/ https://www.ncbi.nlm.nih.gov/pubmed/32017806 http://dx.doi.org/10.1371/journal.ppat.1008222

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